Synthesis and Bioactivity Evaluation of Novel Arylimines Containing a 3-Aminoethyl-2-[(p-trifluoromethoxy)anilino]-4(3H)-quinazolinone Moiety

X Wang, P Li, Z Li, J Yin, M He, W Xue… - Journal of agricultural …, 2013 - ACS Publications
Twenty-seven novel (E)-3-[2-arylideneaminoethyl]-2-[4-(trifluoromethoxy) anilino]-4 (3 H)-
quinazolinone derivatives were synthesized by reacting various aromatic aldehydes with …

Design, synthesis, in silico ADMET profile and GABA‐A docking of novel phthalazines as potent anticonvulsants

AGA El‐Helby, RRA Ayyad, MF Zayed… - Archiv Der …, 2019 - Wiley Online Library
A new series of 2‐substituted‐2, 3‐dihydrophthalazine‐1, 4‐diones (2‒9) were designed
and synthesized to evaluate their anticonvulsant activity. The neurotoxicity was assessed …

[PDF][PDF] Semicarbazone-a versatile therapeutic pharmacophore for fragment based anticonvulsant drug design

SN Pandeya - Acta Pharm, 2012 - sciendo.com
During the last fifteen years, semicarbazones have been extensively investigated for their
anticonvulsant properties. 4-(4-Flurophenoxy) benzaldehyde semicarbazone (C0102862 …

[HTML][HTML] Design, synthesis, molecular docking and anticonvulsant evaluation of novel 6-iodo-2-phenyl-3-substituted-quinazolin-4 (3H)-ones

MK Ibrahim, K El-Adl, AA Al-Karmalawy - Bulletin of Faculty of Pharmacy …, 2015 - Elsevier
A new series of 6-iodo-2-phenyl-3-substituted-quinazolin-4 (3H)-one (5–12 a–b) derivatives
were synthesized, evaluated for their anticonvulsant activity against pentylenetetrazole …

Synthesis, in vivo and in silico anticonvulsant activity studies of new derivatives of 2-(2, 4-dioxo-1, 4-dihydroquinazolin-3 (2H)-yl) acetamide

WM El Kayal, SY Shtrygol, SV Zalevskyi… - European journal of …, 2019 - Elsevier
In order to expand the arsenal of biologically active substances of anticonvulsive action by
the interaction of 2-(2, 4-dioxo-1, 4-dihydroquinazolin-3 (2H)-yl) acetic acid with the …

Microwave-assisted, sequential four-component synthesis of polysubstituted 5, 6-dihydroquinazolinones from acyclic precursors and a mild, halogenation-initiated …

D Rocchi, JF Gonzalez, JC Menéndez - Green Chemistry, 2013 - pubs.rsc.org
A one-pot, microwave-assisted protocol has been developed for the synthesis of 5, 6-
dihydroquinazolinones that incorporate structural fragments from chalcones …

Recent advances in the synthesis and antimicrobial activity of quinazoline derivatives

YL GAO, QZ XIONG, R An, XP BAO - Chinese Journal of Organic …, 2011 - sioc-journal.cn
Quinazoline derivatives have been receiving more and more attention in the fields of
pesticide and medicine due to their extensive biological activities. Introduction of different …

Substituted benzoquinazolinones. Part 1: Synthesis of 6-aminobenzo [h] quinazolinones via Buchwald–Hartwig amination from 6-bromobenzo [h] quinazolinones

M Nowak, Z Malinowski, A Jóźwiak, E Fornal… - Tetrahedron, 2014 - Elsevier
(Morpholin-4-yl) benzo [h] quinazolin-4 (3H)-one derivatives 18a, b were prepared under
Buchwald–Hartwig conditions by reacting 6-bromobenzo [h] quinazolin-4 (3H)-ones 13a, b …

Design, synthesis, docking, and biological evaluation of some novel 5-chloro-2-substituted sulfanylbenzoxazole derivatives as anticonvulsant agents

MK Ibrahim, K El-Adl, MF Zayed, HA Mahdy - Medicinal Chemistry …, 2015 - Springer
In view of their expected anticonvulsant activity, some novel derivatives of 5-chloro-2-
substituted sulfanylbenzoxazoles (5–15f) were synthesized and evaluated for their …

Microwave assisted synthesis of ring junction heterocyclic antioxidants

R Sompalle, SM Roopan - Research on Chemical Intermediates, 2016 - Springer
Abstract A series of 6, 7-dihydro-[1, 2, 4] triazolo [5, 1-b] quinazolin-8 (5 H)-ones, 4a–o were
synthesized via a one-pot, multicomponent reaction in the presence of water as a solvent …