Differentiating between two highly similar C–H bonds in a given molecule remains a
fundamental challenge in synthetic organic chemistry. Directing group assisted strategies for …

In this review, we highlight the journey of C (sp 3)–H activation, how it started and flourished
over the years as well as overcame its shortcomings, to identify future research directions in …

A single-atom iron catalyst was found to exhibit exceptional reactivity in acceptorless
dehydrogenative coupling for quinoline synthesis, outperforming known homogeneous and …

Dehydrogenation chemistry has long been established as a fundamental aspect of organic
synthesis, commonly encountered in carbonyl compounds. Transition metal catalysis …

A direct palladium-catalyzed γ-lactonization of free carboxylic acids via C–O reductive
elimination as a key step is described. Notable aspects of this protocol include the use of …

Aliphatic systems are ubiquitous in numerous natural products and pharmacoactive
compounds. Selective remote C–H functionalization of such aliphatic chains is of great …

Despite recent advances in ligand-enabled C (sp3)–H functionalization of native substrates,
controlling chemoselectivity in the presence of methyl and methylene C (sp3)–H bonds …

In organic synthesis, C (sp3)–H functionalization is a revolutionary method that allows direct
alteration of unactivated C–H bonds. It can obviate the need for pre-functionalization and …

Dehydrogenation of an alkyl group via C–H activation forms a vinyl unit, which can act as a
versatile step** stone for diverse late-stage structural modifications at two adjacent sp 3 …

Aliphatic C (sp3)–H bonds are inherently difficult to activate, owing to their inertness and
chemical indistinguishability. This challenge has been overcome mostly by a directing group …