Isoxazole compounds exhibit a wide spectrum of targets and broad biological activities.
Develo** compounds with heterocycle rings has been one of the trends. The integration of …

Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant
acetylation levels have been linked to the development of several diseases. Acetyl-lysine …

The bromodomain (BrD) is a conserved structural module found in chromatin-and
transcription-associated proteins that acts as the primary reader for acetylated lysine …

Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine
acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in …

The bromodomain is a highly conserved motif of 110 amino acids that is bundled into four
anti-parallel α-helices and found in proteins that interact with chromatin, such as …

BRD4, the most extensively studied member of the BET family, is an epigenetic regulator
that localizes to DNA via binding to acetylated histones and controls the expression of …

Isoxazoles are important five‐membered aromatic heterocycles in organic chemistry.
Recently, many exciting advances in the synthesis and functionalization of isoxazoles have …

Histone acetylation regulates activation and repression of multiple inflammatory genes
known to play critical roles in chronic inflammatory diseases. However, proteins responsible …

ε-N-acetylation of lysine residues (Kac) is one of the most abundant post-translation
modifications (PTMs) in the human proteome. In the nucleus, acetylation of histones has …