Uric acid (UA) is synthesized mainly in the liver, intestines, and vascular endothelium as the
end product of an exogenous purine from food and endogenously from damaged, dying …

Background New drugs and new evidence concerning the use of established treatments
have become available since the publication of the first European League Against …

Gout is a disorder that manifests as a spectrum of clinical and pathologic features built on a
foundation of an excess body burden of uric acid, manifested in part by hyperuricemia …

Gout, a disease recognized since antiquity, has increased in prevalence in recent years and
the clinical profile of this disease has become increasingly complex, owing to large numbers …

There has been increased interest in gout in both academic and clinical practice settings.
Several reasons may explain this. The prevalence of both hyperuricemia and gout has risen …

Objectives Determine the efficacy and safety of daily lesinurad (200 or 400 mg orally) added
to allopurinol in patients with serum uric acid (sUA) above target in a 12-month, randomised …

Gout is the most common inflammatory arthritis worldwide. Although effective treatments
exist to eliminate sodium urate crystals and to'cure'the disease, the management of gout is …

Benzbromarone, a potent uricosuric drug, was introduced in the 1970s and was viewed as
having few associated serious adverse reactions. It was registered in about 20 countries …

Allopurinol is the drug most widely used to lower the blood concentrations of urate and,
therefore, to decrease the number of repeated attacks of gout. Allopurinol is rapidly and …

Objectives To compare the efficacy and tolerability of allopurinol 300–600 mg/day versus
benzbromarone 100–200 mg/day used to attain a target serum urate concentration (sUr)⩽ …