Supramolecular chemistry combines the strength of molecular assembly via various
molecular interactions. Hydrogen bonding facilitated self-assembly with the advantages of …

The insulin receptor (IR) gene undergoes differential splicing that generates two IR isoforms,
IR-A and IR-B. The physiological roles of IR isoforms are incompletely understood and …

Recent advances in understanding different RNAs and unique features of their biology have
revealed a wealth of information. However, approaches to identify small molecules that …

The development of innovative methodologies to identify RNA binders has attracted
enormous attention in chemical biology and drug discovery. Although antibiotics targeting …

Muscleblind-like (MBNL) proteins are key regulators of precursor and mature mRNA
metabolism in mammals. Based on published and novel data, we explore models of tissue …

Single-agent, single-target therapeutic approaches are often limited by a complex disease
pathobiology. We report rationally designed, multi-target agents for myotonic dystrophy type …

A small molecule (1) with overlap** affinity for two microRNA (miRNA) precursors was
used to inform design of a dimeric compound (2) selective for one of the miRNAs. In …

RNA is one of the most intriguing and promising biological targets for the discovery of
innovative drugs in many pathologies and various biologically relevant RNAs that could …

Rapid progress in genome sequencing technology has put us firmly into a postgenomic era.
A key challenge in biomedical research is harnessing genome sequence to fulfill the …

Over the past decade, the RNA revolution has revealed thousands of non-coding RNAs that
are essential for cellular regulation and are misregulated in disease. While the development …