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An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …
Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete ty** units (DTUs) …
widely recognized. At present, T. cruzi is partitioned into seven discrete ty** units (DTUs) …
Chagas' disease
Chagas’ Disease | New England Journal of Medicine Skip to main content The New England
Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical …
Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical …
Hit and lead criteria in drug discovery for infectious diseases of the develo** world
Reducing the burden of infectious diseases that affect people in the develo** world
requires sustained collaborative drug discovery efforts. The quality of the chemical starting …
requires sustained collaborative drug discovery efforts. The quality of the chemical starting …
[HTML][HTML] Advances in the treatment of Chagas disease: Promising new drugs, plants and targets
Chagas disease, caused by Trypanosoma cruzi, is treated with only two drugs;
benznidazole and nifurtimox. These drugs have some disadvantages, including their …
benznidazole and nifurtimox. These drugs have some disadvantages, including their …
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and slee** sickness
S Khare, AS Nagle, A Biggart, YH Lai, F Liang… - Nature, 2016 - nature.com
Chagas disease, leishmaniasis and slee** sickness affect 20 million people worldwide
and lead to more than 50,000 deaths annually. The diseases are caused by infection with …
and lead to more than 50,000 deaths annually. The diseases are caused by infection with …
Secondary metabolites from endophytic fungi: Production, methods of analysis, and diverse pharmaceutical potential
The synthesis of secondary metabolites is a constantly functioning metabolic pathway in all
living systems. Secondary metabolites can be broken down into numerous classes …
living systems. Secondary metabolites can be broken down into numerous classes …
Challenges and recent progress in drug discovery for tropical diseases
Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and
impose a heavy economic burden on affected countries. These diseases predominantly …
impose a heavy economic burden on affected countries. These diseases predominantly …
Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …
Clinical and pharmacological profile of benznidazole for treatment of Chagas disease
Introduction: Chagas disease (CD) is one of the most neglected public health problems in
the Americas, where< 1% of the estimated 6 million people with the infection have been …
the Americas, where< 1% of the estimated 6 million people with the infection have been …