Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …

PARPs and tankyrases (TNKS) represent a family of 17 proteins. PARPs and tankyrases
were originally identified as DNA repair factors, nevertheless, recent advances have shed …

Background Co-inhibition of poly (ADP-ribose) polymerase (PARP) and androgen receptor
activity might result in antitumour efficacy irrespective of alterations in DNA damage repair …

Preclinical evidence has suggested an interplay between the androgen receptor, which
largely drives the growth of prostate cancer cells, and poly (ADP-ribose) polymerase. This …

Owing to the development of multiple novel therapies, there has been major progress in the
treatment of advanced prostate cancer over the last two decades; however, the disease …

Prostate cancer is the most commonly diagnosed non-cutaneous cancers in North American
men. While androgen deprivation has remained as the cornerstone of prostate cancer …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Abstract FOXA1 (Forkhead Box A1) and FOXA2 (Forkhead Box A2) serve as pioneering
transcription factors that build gene expression capacity and play a central role in biological …

Neuroendocrine prostate cancer is a histological variant of prostate cancer that is
characterized by aggressiveness, poor clinical outcomes, and expression of neuroendocrine …

Prostate cancer is the second most common malignancy in men and androgen deprivation
therapy is the first‐line therapy. However, most cases will eventually develop castration …