Status and prospects of genome‐wide association studies in plants

L Tibbs Cortes, Z Zhang, J Yu - The plant genome, 2021 - Wiley Online Library
Genome‐wide association studies (GWAS) have developed into a powerful and ubiquitous
tool for the investigation of complex traits. In large part, this was fueled by advances in …

Salt stress under the scalpel–dissecting the genetics of salt tolerance

MJL Morton, M Awlia, N Al‐Tamimi, S Saade… - The Plant …, 2019 - Wiley Online Library
Salt stress limits the productivity of crops grown under saline conditions, leading to
substantial losses of yield in saline soils and under brackish and saline irrigation. Salt …

A generalized linear mixed model association tool for biobank-scale data

L Jiang, Z Zheng, H Fang, J Yang - Nature genetics, 2021 - nature.com
Compared with linear mixed model-based genome-wide association (GWA) methods,
generalized linear mixed model (GLMM)-based methods have better statistical properties …

A transcriptional regulator that boosts grain yields and shortens the growth duration of rice

S Wei, X Li, Z Lu, H Zhang, X Ye, Y Zhou, J Li, Y Yan… - Science, 2022 - science.org
Complex biological processes such as plant growth and development are often under the
control of transcription factors that regulate the expression of large sets of genes and …

GAPIT version 3: boosting power and accuracy for genomic association and prediction

J Wang, Z Zhang - Genomics, Proteomics and Bioinformatics, 2021 - academic.oup.com
Genome-wide association study (GWAS) and genomic prediction/selection (GP/GS) are the
two essential enterprises in genomic research. Due to the great magnitude and complexity …

rMVP: a memory-efficient, visualization-enhanced, and parallel-accelerated tool for genome-wide association study

L Yin, H Zhang, Z Tang, J Xu, D Yin… - Genomics …, 2021 - academic.oup.com
Along with the development of high-throughput sequencing technologies, both sample size
and SNP number are increasing rapidly in genome-wide association studies (GWAS), and …

Computationally efficient whole-genome regression for quantitative and binary traits

J Mbatchou, L Barnard, J Backman, A Marcketta… - Nature …, 2021 - nature.com
Genome-wide association analysis of cohorts with thousands of phenotypes is
computationally expensive, particularly when accounting for sample relatedness or …

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

W Zhou, JB Nielsen, LG Fritsche, R Dey… - Nature …, 2018 - nature.com
In genome-wide association studies (GWAS) for thousands of phenotypes in large biobanks,
most binary traits have substantially fewer cases than controls. Both of the widely used …

A resource-efficient tool for mixed model association analysis of large-scale data

L Jiang, Z Zheng, T Qi, KE Kemper, NR Wray… - Nature …, 2019 - nature.com
The genome-wide association study (GWAS) has been widely used as an experimental
design to detect associations between genetic variants and a phenotype. Two major …

Genome-wide dissection of changes in maize root system architecture during modern breeding

W Ren, L Zhao, J Liang, L Wang, L Chen, P Li, Z Liu… - Nature Plants, 2022 - nature.com
Appropriate root system architecture (RSA) can improve maize yields in densely planted
fields, but little is known about its genetic basis in maize. Here we performed root …