The ubiquitin system has become synonymous with the modification of lysine residues.
However, the substrate scope and diversity of the conjugation machinery have been …

The formation of synapses in the vertebrate central nervous system is a complex process
that occurs over a protracted period of development. Recent work has begun to unravel the …

Amyotrophic lateral sclerosis (ALS) is a disease characterized by upper and lower motor
neuron (MN) loss with a signature feature of cytoplasmic aggregates containing TDP-43 …

Synapses display a stereotyped ultrastructural organization, commonly containing a single
electron-dense presynaptic density surrounded by a cluster of synaptic vesicles. The …

Highwire is an extremely large, evolutionarily conserved E3 ubiquitin ligase that negatively
regulates synaptic growth at the Drosophila NMJ. Highwire has been proposed to restrain …

Neurons are highly specialized cells whose connectivity at synapses subserves rapid
information transfer in the brain. Proper information processing, learning, and memory …

MYCBP2 is a ubiquitin (Ub) E3 ligase (E3) that is essential for neurodevelopment and
regulates axon maintenance. MYCBP2 transfers Ub to nonlysine substrates via a newly …

Of the many inherited Charcot-Marie-Tooth peripheral neuropathies, type 2D (CMT2D) is
caused by dominant point mutations in the gene GARS, encoding glycyl tRNA synthetase …

The clinical impact of rare loss-of-function variants has yet to be determined for most genes.
Integration of DNA sequencing data with electronic health records (EHRs) could enhance …

Axonal degeneration is a hallmark of many neuropathies, neurodegenerative diseases, and
injuries. Here, using a Drosophila injury model, we have identified a highly conserved E3 …