For about half a century, the binding of drugs to plasma albumin, the “silent receptor,” has
been recognized as one of the major determinants of drug action, distribution, and …

Cytokines, signaling molecules of the immune system, have been implicated as a
contributing factor for mood disorders such as depression. Several lines of evidence …

Cytokines whose primary function is that of acting as signaling molecules of the immune
system, have been implicated in the provocation or exacerbation of mood disorders such as …

BACKGROUND: Recurrent major depression is associated with decreased blood zinc
concentrations that may be increased by effective antidepressant therapy. Some clinical …

Major psychiatric disorders such as schizophrenia, major depressive and bipolar disorders
are severe, chronic and debilitating, and are associated with high disease burden and …

Stressful events have been implicated in the provocation of depressive illness. Inasmuch as
immunological challenge, and particularly cytokine administration, engender …

It is important to differentiate between bipolar disorder (BD) and major depressive disorder
(MDD) in the first depressive episode because of the potential treatment implications …

Tricyclic antidepressants (TCAs) are frequently prescribed in case of non-response to first-
line antidepressants in Major Depressive Disorder (MDD). Treatment of MDD often entails a …

Trigeminal neuralgia (TN) with chronic and severe neuropathic pain leads to remarkable
interference in daily living activities of patients. Unknown molecular mechanisms involved in …

Less than a decade has elapsed since the publication in 2000 of the first anthology devoted
to lipocalins (Biochim Biophys Acta 1482, 2000), and only a few years since the first …