Molecular hybridization is a new concept in drug design and development based on the
combination of pharmacophoric moieties of different bioactive substances to produce a new …

The quinoline ring system1-5 is present in a number of natural6 and synthetic products often
endowed with interesting pharmacological or physical properties. 7, 8 Consequently, a …

Acetylcholinesterase is a member of the α/β hydrolase protein super family, with a significant
role in acetylcholine-mediated neurotransmission. Research in the modulators of AChEs …

Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …

From Curcuma longa, two novel compounds, 4 ''-(3 '''-methoxy-4 '''-hydroxyphenyl)-2 ''-oxo-3
''-enebutanyl 3-(3 '-methoxy-4 'hydroxyphenyl) propenoate (calebin-A, 1) and 1, 7-bis (4 …

β-Amyloid (βA) induced oxidative stress is a well-established pathway of neuronal cell death
in Alzheimer's disease. From turmeric, Curcuma longa L.(Zingiberaceae), three …

In this article the design of hybrid molecules that covalently connect two distinct drug entities
in one molecule, at least one part being a biologically active natural product will be …

Several new 12-amino-6, 7, 10, 11-tetrahydro-7, 11-methanocycloocta [b] quinoline
derivatives (tacrine− huperzine A hybrids, huprines) have been synthesized and tested as …

Alzheimer's disease (AD) is a complex neurodegenerative condition with several target
proteins contributing to its etiology. With 35.6 million cases worldwide documented in 2011 …

Huprine X is a novel acetylcholinesterase (AChE) inhibitor, with one of the highest affinities
reported for a reversible inhibitor. It is a synthetic hybrid that contains the 4-aminoquinoline …