Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …

Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are
derived from cells with stem potential and can self‐organize and differentiate into 3D cell …

Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …

Thanks to progress in the development of three‐dimensional (3D) culture technologies,
human central nervous system (CNS) development and diseases have been gradually …

Cancer therapies have several clinical challenges associated with them, namely treatment
toxicity, treatment resistance and relapse. Due to factors ranging from patient profiles to the …

Organoids are miniature, highly accurate representations of organs that capture the structure
and unique functions of specific organs. Although the field of organoids has experienced …

Diseases leading to retinal cell loss can cause severe visual impairment and blindness. The
lack of effective therapies to address retinal cell loss and the absence of intrinsic …

Human-induced pluripotent stem cells (hiPSCs) have provided new methods to study
neurodegenerative diseases. In addition to their wide application in neuronal disorders …

Retinoblastoma is a retinal cancer that affects children and is the most prevalent intraocular
tumor worldwide. Despite tremendous breakthroughs in our understanding of the …

Retinoblastoma (Rb) is a type of malignant tumor due to abnormal retinogenesis with
biallelic mutations of the RB1 gene. Its pathogenesis has been proposed as a “two-mutation …