Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein
profiling methods as a major pillar for cellular atlas building of complex samples, from …

BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

Emotional states influence bodily physiology, as exemplified in the top-down process by
which anxiety causes faster beating of the heart,–. However, whether an increased heart …

Genetic risk for autism spectrum disorder (ASD) is associated with hundreds of genes
spanning a wide range of biological functions,,,,–. The alterations in the human brain …

Neuronal ensembles that hold specific memory (memory engrams) have been identified in
the hippocampus, amygdala, or cortex. However, it has been hypothesized that engrams of …

Whole-body imaging techniques play a vital role in exploring the interplay of physiological
systems in maintaining health and driving disease. We introduce wildDISCO, a new …

State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light …

When used appropriately, a confocal fluorescence microscope is an excellent tool for
making quantitative measurements in cells and tissues. The confocal microscope's ability to …

Lung transplantation can potentially be a life-saving treatment for patients with nonresolving
COVID-19–associated respiratory failure. Concerns limiting lung transplantation include …

Tissue clearing of gross anatomical samples was first described more than a century ago
and has only recently found widespread use in the field of microscopy. This renaissance has …