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The impact of drug resistance on Mycobacterium tuberculosis physiology: what can we learn from rifampicin?
The emergence of drug-resistant pathogens poses a major threat to public health. Although
influenced by multiple factors, high-level resistance is often associated with mutations in …
influenced by multiple factors, high-level resistance is often associated with mutations in …
Nontuberculous mycobacteria and heterologous immunity to tuberculosis
Abstract Development of an improved tuberculosis (TB) vaccine is a high worldwide public
health priority. Bacillus Calmette-Guerin (BCG), the only licensed TB vaccine, provides …
health priority. Bacillus Calmette-Guerin (BCG), the only licensed TB vaccine, provides …
Antibody Fc glycosylation discriminates between latent and active tuberculosis
Background Mycobacterium tuberculosis remains a global health problem and clinical
management is complicated by difficulty in discriminating between latent infection and active …
management is complicated by difficulty in discriminating between latent infection and active …
Mycobacterium tuberculosis proteome microarray for global studies of protein function and immunogenicity
J Deng, L Bi, L Zhou, S Guo, J Fleming, H Jiang… - Cell reports, 2014 - cell.com
Poor understanding of the basic biology of Mycobacterium tuberculosis (MTB), the
etiological agent of tuberculosis, hampers development of much-needed drugs, vaccines …
etiological agent of tuberculosis, hampers development of much-needed drugs, vaccines …
Multiparameter immunoprofiling for the diagnosis and differentiation of progressive versus nonprogressive nontuberculous mycobacterial lung disease–A pilot study
Clinical prediction of nontuberculous mycobacteria lung disease (NTM-LD) progression
remains challenging. We aimed to evaluate antigen-specific immunoprofiling utilizing flow …
remains challenging. We aimed to evaluate antigen-specific immunoprofiling utilizing flow …
Proteomic characterisation of bovine and avian purified protein derivatives and identification of specific antigens for serodiagnosis of bovine tuberculosis
Background Bovine purified protein derivative (bPPD) and avian purified protein derivative
(aPPD) are widely used for bovine tuberculosis diagnosis. However, little is known about …
(aPPD) are widely used for bovine tuberculosis diagnosis. However, little is known about …
Mycobacteria-Specific T Cells Are Generated in the Lung During Mucosal BCG Immunization or Infection With Mycobacterium tuberculosis
Specific T cell responses are central for protection against infection with M. tuberculosis.
Here we show that mycobacteria-specific CD4 and CD8 T cells accumulated in the lung but …
Here we show that mycobacteria-specific CD4 and CD8 T cells accumulated in the lung but …
Nonmolecular methods for the diagnosis of respiratory fungal infections
F Lamoth, BD Alexander - Clinics in laboratory medicine, 2014 - labmed.theclinics.com
Fungal pneumonias are an important cause of mortality among an increasing diversity of
immunosuppressed populations, such as patients who have hematologic cancer, transplant …
immunosuppressed populations, such as patients who have hematologic cancer, transplant …
[PDF][PDF] The role of protein aggregation in the pathogenesis of inclusion body myositis
AM Snedden, KAB Kellett, JB Lilleker… - Clin Exp …, 2022 - researchgate.net
Inclusion body myositis (IBM) is characterised by infiltration of CD8+ T-cells and signs of
protein aggregation such as rimmed vacuoles and inclusion bodies. Aggregated proteins …
protein aggregation such as rimmed vacuoles and inclusion bodies. Aggregated proteins …
Comparative Genomics and Proteomic Analysis of Four Non-tuberculous Mycobacterium Species and Mycobacterium tuberculosis Complex: Occurrence of Shared …
The Esx and PE/PPE families of proteins are among the most immunodominant
mycobacterial antigens and have thus been the focus of research to develop vaccines and …
mycobacterial antigens and have thus been the focus of research to develop vaccines and …