Androgens and androgen receptors (AR) play a pivotal role in expression of the male
phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate …

Ligands for the nuclear receptor superfamily control many aspects of biology, including
development, reproduction, and homeostasis, through regulation of the transcriptional …

The androgen receptor (AR) is a nuclear receptor transcription factor that mediates the
cellular actions of androgens, the male sex steroids. Androgen-dependent tissues, such as …

Nuclear receptors (also known as nuclear hormone receptors) are hormone-regulated
transcription factors that control many important physiological and developmental processes …

The androgen receptor signaling axis plays an essential role in the development, function
and homeostasis of male urogenital structures including the prostate gland although the …

Post-translational modification with the ubiquitin-like SUMO protein is involved in the
regulation of many cellular key processes. The SUMO system modulates signal transduction …

Medullary thyroid carcinomas (MTC) arise from thyroid parafollicular, calcitonin-producing C-
cells and can occur either as sporadic or as hereditary diseases in the context of familial …

Steroid hormones are important endocrine signalling molecules controlling reproduction,
development, metabolism, salt balance and specialized cellular responses, such as …

While the structures of the DNA-and ligand-binding domains of many nuclear receptors have
been determined in great detail; the mechanisms by which these domains interact and …

The categorization of prostate cancers that are progressing after castration as 'hormone-
refractory'evolved from the clinical observation that surgical or medical castration (ie …