Dopamine is a prototypical neuromodulator that controls circuit function through G protein-
coupled receptor signalling. Neuromodulators are volume transmitters, with release followed …

The'one neuron, one neurotransmitter'doctrine states that synaptic communication between
two neurons occurs through the release of a single chemical transmitter. However, recent …

Highlights•Striatal dopamine release is mediated by vesicular exocytosis.•Active zone-like
sites are required for rapid and efficient dopamine secretion.•Localized dopamine release …

Chemical signaling through the release of neurotransmitters into the extracellular space is
the primary means of communication between neurons. More than four decades ago, Ralph …

Circadian rhythms are daily rhythms that regulate many biological processes–from gene
transcription to behavior–and a disruption of these rhythms can lead to a myriad of health …

Synaptic transmission between midbrain dopamine neurons and target neurons in the
striatum is essential for the selection and reinforcement of movements. Recent evidence …

Highlights•Co-release and co-transmission are distinct, separate modes of release.•There
are multiple classes of dual-transmitter neurons.•The consequence of co-release extends …

Odors elicit distributed activation of glomeruli in the olfactory bulb (OB). Crosstalk between
co-active glomeruli has been proposed to perform a variety of computations, facilitating …

Synaptic inhibition critically influences sensory processing throughout the mammalian brain,
including the main olfactory bulb (MOB), the first station of sensory processing in the …

Methamphetamine (METH) is a potent psychostimulant that increases extracellular
monoamines, such as dopamine and norepinephrine, and affects multiple tissue and cell …