Heart failure is associated with generalized insulin resistance. Moreover, insulin-resistant
states such as type 2 diabetes mellitus and obesity increases the risk of heart failure even …

The heart hypertrophies in response to developmental signals as well as increased
workload. Although adult-onset hypertrophy can ultimately lead to disease, cardiac …

Global climate change has a significant effect on extreme environments and a profound
influence on species survival. However, little is known of the genome-wide pattern of …

RESULTS mTORC1 regulates glucose uptake and glycolysis in TCR-and IL-2–stimulated
CD8+ T cells TCR triggering of naive CD8+ T cells with peptide–MHC complexes induced …

A highly conserved signaling pathway involving insulin-like growth factor 1 (IGF1), and a
cascade of intracellular components that mediate its effects, plays a major role in the …

Cell growth (an increase in cell mass and size through macromolecular biosynthesis) and
cell cycle progression are generally tightly coupled, allowing cells to proliferate continuously …

The interaction of insulin and growth factors with their receptors on the outside surface of a
cell, leads to the activation of phosphatidylinositol 3-kinase (PI 3-kinase) and generation of …

Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in
heart attacks and strokes, the most common causes of death in developed countries. Large …

Rational target therapy of cancer would benefit from the identification of new targets that can
be easily inhibited by small molecules. An increasing amount of evidence hints at 3 …

Studies of Drosophila and mammals have revealed the importance of insulin signaling
through phosphatidylinositol 3-kinase and the serine/threonine kinase Akt/protein kinase B …