This narrative review represents an output from the International Association for the Study of
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …

Cannabinoids, when co-administered with opioids, may enable reduced opioid doses
without loss of analgesic efficacy (ie, an opioid-sparing effect). The aim of this study was to …

The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

Freund, Tamás F., István Katona, and Daniele Piomelli. Role of Endogenous Cannabinoids
in Synaptic Signaling. Physiol Rev 83: 1017–1066, 2003; 10.1152/physrev. 00004.2003 …

CB 1 cannabinoid receptors appear to mediate most, if not all of the psychoactive effects of
delta-9-tetrahydrocannabinol and related compounds. This G protein-coupled receptor has …

The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …

Mammalian tissues contain at least two types of cannabinoid receptor, CB1 and CB2, both
coupled to G proteins. CB1 receptors are expressed mainly by neurones of the central and …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …

This article reviews recent research on cannabinoid analgesia via the endocannabinoid
system and non-receptor mechanisms, as well as randomized clinical trials employing …

Neuropathic pain is defined as 'pain initiated or caused by a primary lesion or dysfunction in
the nervous system'. 94 The spectrum of neuropathic pain covers a variety of disease states …