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Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52105121&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
52105121&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49883289&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49883289&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Functional genomics using CRISPR-Cas systems, compositions, methods, screens and applications thereof
2016-06-20 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for targeting disorders and diseases using viral components
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
52105124&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
52105124&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Methods, models, systems, and apparatus for identifying target sequences for Cas enzymes or CRISPR-Cas systems for target sequences and conveying results …
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49881142&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49881142&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
F Zhang, C Lin, RAN Fei - US Patent 11,008,588, 2021 - Google Patents
2016-06-20 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
Compositions and methods of use of CRISPR-Cas systems in nucleotide repeat disorders
B Davidson, C Lin, E Rodriguez, F Zhang - US Patent 10,851,357, 2020 - Google Patents
2017-12-15 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for genome editing
2016-09-28 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
Protected guide rnas (pgrnas)
2017-09-06 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …
Second-shell basic residues expand the two-metal-ion architecture of DNA and RNA processing enzymes
Synthesis and scission of phosphodiester bonds in DNA and RNA regulate vital processes
within the cell. Enzymes that catalyze these reactions operate mostly via the recognized two …
within the cell. Enzymes that catalyze these reactions operate mostly via the recognized two …