This theoretical article revives a classical bridging construct, canalization, to describe a new
model of a general factor of psychopathology. To achieve this, we have distinguished …

What can be expected in normal aging, and where does normal aging stop and pathological
neurodegeneration begin? With the slow progression of age-related dementias such as …

Abstract Information processing in specialized, spatially distributed brain networks underlies
the diversity and complexity of our cognitive and behavioral repertoire. Networks converge …

Human cortical thickness and surface area are genetically independent, emerge through
different neurobiological events during development, and are sensitive to different clinical …

To understand the emergence of human higher cognition, we must understand its biological
substrate—the cerebral cortex, which considers itself the crowning achievement of evolution …

Human higher cognition is attributed to the evolutionary expansion and elaboration of the
human cerebral cortex. However, the genetic mechanisms contributing to these …

A suite of recent studies has reported positive genetic correlations between autism risk and
measures of mental ability. These findings indicate that alleles for autism overlap broadly …

Magnetic resonance imaging (MRI) has allowed the unprecedented capability to measure
the human brain in vivo. This technique has paved the way for longitudinal studies exploring …

Growing access to large-scale longitudinal structural neuroimaging data has fundamentally
altered our understanding of cortical development en route to human adulthood, with …

Neurodevelopmental origins of functional variation in older age are increasingly being
acknowledged, but identification of how early factors impact human brain and cognition …