Three family members compose the pannexin family of channel-forming glycoproteins
(Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single …

Pannexins, a class of membrane channels, bear significant sequence homology with the
invertebrate gap junction proteins, innexins, and more distant similarities in their membrane …

Purpose Microglia represent the primary resident immune cells in the CNS, and have been
implicated in the pathology of neurodegenerative diseases. Under basal or “resting” …

Connexin channels are known to be permeable to a variety of cytoplasmic molecules. The
first observation of second messenger junctional permeability, made∼ 30 years ago …

Purinergic signaling plays distinct and important roles in the CNS, including the transmission
of calcium signals between astrocytes. Gap junction hemichannels are among the …

Pannexins are large-pore ion channels with broad expression in the central nervous system
(CNS). The channels function by releasing large signaling molecules, such ATP and …

The pannexin family of mammalian proteins, composed of Panx1, Panx2, and Panx3, has
been postulated to be a new class of single-membrane channels with functional similarities …

Tonic motor control involves oscillatory synchronization of activity at low frequency (5–30
Hz) throughout the sensorimotor system, including cerebellar areas. We investigated the …

The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap
junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and …

Neuroinflammation is a major component of central nervous system (CNS) injuries and
neurological diseases, including Alzheimer's disease, multiple sclerosis, neuropathic pain …