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Cholinesterase inhibitors as Alzheimer's therapeutics
K Sharma - Molecular medicine reports, 2019 - spandidos-publications.com
Alzheimer's disease (AD) is one of the most common forms of dementia. AD is a chronic
syndrome of the central nervous system that causes a decline in cognitive function and …
syndrome of the central nervous system that causes a decline in cognitive function and …
Molecular dynamics-driven drug discovery: lea** forward with confidence
Highlights•Currently, develo** a market-approved drug costs a staggering $2.6 billion.•In
silico methods have become an important strategy for narrowing down on promising lead …
silico methods have become an important strategy for narrowing down on promising lead …
Multi-target design strategies for the improved treatment of Alzheimer's disease
P Zhang, S Xu, Z Zhu, J Xu - European journal of medicinal chemistry, 2019 - Elsevier
Alzheimer's disease (AD) is a multifactorial syndrome resulting in profound misery and
poses a substantial burden on human health, economy, and society throughout the world …
poses a substantial burden on human health, economy, and society throughout the world …
Molecular hybridization: a useful tool in the design of new drug prototypes
Molecular hybridization is a new concept in drug design and development based on the
combination of pharmacophoric moieties of different bioactive substances to produce a new …
combination of pharmacophoric moieties of different bioactive substances to produce a new …
Recent advances in the Friedlander reaction
The quinoline ring system1-5 is present in a number of natural6 and synthetic products often
endowed with interesting pharmacological or physical properties. 7, 8 Consequently, a …
endowed with interesting pharmacological or physical properties. 7, 8 Consequently, a …
Acetylcholinesterase inhibitory potential of various sesquiterpene analogues for Alzheimer's disease therapy
Alzheimer's disease (AD) is a gradually growing irreversible illness of the brain that almost
affects every fifth person (aged> 80 years) in the world. World Health Organization (WHO) …
affects every fifth person (aged> 80 years) in the world. World Health Organization (WHO) …
Multifunctional compounds: Smart molecules for multifactorial diseases
Multifunctional compounds (MFCs) are designed broadly as hybrid or conjugated drugs or
as chimeric drugs from two or more pharmacophores/drugs having specific pharmacological …
as chimeric drugs from two or more pharmacophores/drugs having specific pharmacological …
The multifactorial nature of Alzheimer's disease for develo** potential therapeutics
M Carmo Carreiras, E Mendes… - Current topics in …, 2013 - ingentaconnect.com
Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998–2018)
Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …
neurodegenerative disorder of the brain which involves multiple associated etiological …
Alzheimer's disease, enzyme targets and drug discovery struggles: from natural products to drug prototypes
Alzheimer's disease (AD) is an incapacitating neurodegenerative disease that slowly
destroys brain cells. This disease progressively compromises both memory and cognition …
destroys brain cells. This disease progressively compromises both memory and cognition …