Recent advances in nanoparticulate RNA delivery systems

J Witten, Y Hu, R Langer, DG Anderson - Proceedings of the National …, 2024 - pnas.org
Nanoparticle-based RNA delivery has shown great progress in recent years with the
approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 …

Circular RNA in cancer

VM Conn, AM Chinnaiyan, SJ Conn - Nature Reviews Cancer, 2024 - nature.com
Over the past decade, circular RNA (circRNA) research has evolved into a bona fide
research field shedding light on the functional consequence of this unique family of RNA …

From structural design to delivery: mRNA therapeutics for cancer immunotherapy

F Zhou, L Huang, S Li, W Yang, F Chen, Z Cai… - …, 2024 - Wiley Online Library
Abstract mRNA therapeutics have emerged as powerful tools for cancer immunotherapy in
accordance with their superiority in expressing all sequence‐known proteins in vivo. In …

Recent progress in mRNA cancer vaccines

R Yao, C **e, X **a - Human Vaccines & Immunotherapeutics, 2024 - Taylor & Francis
The research and development of messenger RNA (mRNA) cancer vaccines have gradually
overcome numerous challenges through the application of personalized cancer antigens …

Charge-altering releasable transporters enhance mRNA delivery in vitro and exhibit in vivo tropism

Z Li, L Amaya, R Pi, SK Wang, A Ranjan… - Nature …, 2023 - nature.com
The introduction of more effective and selective mRNA delivery systems is required for the
advancement of many emerging biomedical technologies including the development of …

Advances and applications of RNA vaccines in tumor treatment

R Yang, J Cui - Molecular Cancer, 2024 - Springer
Compared to other types of tumor vaccines, RNA vaccines have emerged as promising
alternatives to conventional vaccine therapy due to their high efficiency, rapid development …

Advanced technologies for the development of infectious disease vaccines

A Gupta, A Rudra, K Reed, R Langer… - Nature Reviews Drug …, 2024 - nature.com
Vaccines play a critical role in the prevention of life-threatening infectious disease. However,
the development of effective vaccines against many immune-evading pathogens such as …

Pathways for macrophage uptake of cell-free circular RNAs

L Amaya, B Abe, J Liu, F Zhao, WL Zhang, R Chen… - Molecular cell, 2024 - cell.com
Circular RNAs (circRNAs) are stable RNAs present in cell-free RNA, which may comprise
cellular debris and pathogen genomes. Here, we investigate the phenomenon and …

Translational adaptation in breast cancer metastasis and emerging therapeutic opportunities

S Chen, A Navickas, H Goodarzi - Trends in Pharmacological Sciences, 2024 - cell.com
Breast cancer's tendency to metastasize poses a critical barrier to effective treatment,
making it a leading cause of mortality among women worldwide. A growing body of …

Organ-and cell-selective delivery of mRNA in vivo using guanidinylated serinol charge-altering releasable transporters

Z Li, L Amaya, A Ee, SK Wang, A Ranjan… - Journal of the …, 2024 - ACS Publications
Selective RNA delivery is required for the broad implementation of RNA clinical applications,
including prophylactic and therapeutic vaccinations, immunotherapies for cancer, and …