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PDE4 inhibitors: potential protective effects in inflammation and vascular diseases
T Fan, W Wang, Y Wang, M Zeng, Y Liu… - Frontiers in …, 2024 - frontiersin.org
Phosphodiesterase 4 (PDE4) inhibitors are effective therapeutic agents for various
inflammatory diseases. Roflumilast, apremilast, and crisaborole have been developed and …
inflammatory diseases. Roflumilast, apremilast, and crisaborole have been developed and …
[HTML][HTML] Beyond PDE4 inhibition: A comprehensive review on downstream cAMP signaling in the central nervous system
Z Donders, IJ Skorupska, E Willems, F Mussen… - Biomedicine & …, 2024 - Elsevier
Cyclic adenosine monophosphate (cAMP) is a key second messenger that regulates signal
transduction pathways pivotal for numerous biological functions. Intracellular cAMP levels …
transduction pathways pivotal for numerous biological functions. Intracellular cAMP levels …
Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology
Inhibition of phosphodiesterase 4D (PDE4D) enzymes has been investigated as therapeutic
strategy to treat memory problems in Alzheimer's disease (AD). Although PDE4D inhibitors …
strategy to treat memory problems in Alzheimer's disease (AD). Although PDE4D inhibitors …
Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination
The precise neurophysiological changes prompted by meningeal lymphatic dysfunction
remain unclear. Here, we showed that inducing meningeal lymphatic vessel ablation in adult …
remain unclear. Here, we showed that inducing meningeal lymphatic vessel ablation in adult …
[HTML][HTML] PDE4D: a multipurpose pharmacological target
M Lusardi, F Rapetti, A Spallarossa… - International Journal of …, 2024 - mdpi.com
Phosphodiesterase 4 (PDE4) enzymes catalyze cyclic adenosine monophosphate (cAMP)
hydrolysis and are involved in a variety of physiological processes, including brain function …
hydrolysis and are involved in a variety of physiological processes, including brain function …
Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment
Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–
brain barrier impairments which play a key role in the development of white matter lesions …
brain barrier impairments which play a key role in the development of white matter lesions …
Induced pluripotent stem cells and organoids in advancing neuropathology research and therapies
DB Pazzin, TTR Previato, JI Budelon Gonçalves… - Cells, 2024 - mdpi.com
This review delves into the groundbreaking impact of induced pluripotent stem cells (iPSCs)
and three-dimensional organoid models in propelling forward neuropathology research …
and three-dimensional organoid models in propelling forward neuropathology research …
Unleashing spinal cord repair: the role of cAMP-specific PDE inhibition in attenuating neuroinflammation and boosting regeneration after traumatic spinal cord injury
Traumatic spinal cord injury (SCI) is characterized by severe neuroinflammation and
hampered neuroregeneration, which often leads to permanent neurological deficits. Current …
hampered neuroregeneration, which often leads to permanent neurological deficits. Current …
Short PDE4 isoforms as drug targets in disease
The second messenger, cyclic adenosine monophosphate (cAMP), is a master regulator of
signal transduction that maintains cell homeostasis. A fine balance between cAMP synthesis …
signal transduction that maintains cell homeostasis. A fine balance between cAMP synthesis …
[HTML][HTML] Roflumilast and cognition enhancement: A translational perspective
Cognitive impairment affiliated with neurological disorders has a severe impact on daily life
functioning and the quality of life of patients. This is associated with a significant and long …
functioning and the quality of life of patients. This is associated with a significant and long …