Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …

The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

The development of single-cell multi-omics technology has greatly enhanced our
understanding of biology, and in parallel, numerous algorithms have been proposed to …

High-throughput single-cell profiling provides an unprecedented ability to uncover the
molecular states of millions of cells. These technologies are, however, destructive to cells …

Assessment of single-cell gene expression (single-cell RNA sequencing) and adaptive
immune receptor (AIR) sequencing (scVDJ-seq) has been invaluable in studying …

Harmonizing cell types across the single-cell community and assembling them into a
common framework is central to building a standardized Human Cell Atlas. Here, we present …

The rapid adoption of single-cell technologies has created an opportunity to build single-cell
'atlases' integrating diverse datasets across many laboratories. Such atlases can serve as a …

Cells are the fundamental units of biological systems and exhibit unique development
trajectories and molecular features. Our exploration of how the genomes orchestrate the …

Background Single-cell RNA-sequencing (scRNA-seq) measures gene expression in single
cells, while single-nucleus ATAC-sequencing (snATAC-seq) quantifies chromatin …

Abstract Analysis across a growing number of single-cell perturbation datasets is hampered
by poor data interoperability. To facilitate development and benchmarking of computational …