Folding and Misfolding Dynamics of Irisin Protein Revealed by Single-Molecule Magnetic Tweezers

J Xu, H Sun, Z Zhang, Z Guo, S Le… - The Journal of Physical …, 2024 - ACS Publications
Irisin, a fibronectin III protein secreted by muscles during physical exercise, plays a
significant role in the browning of white fat and cell adhesion, highlighting the importance of …

Ligand-dependent folding and unfolding dynamics and free energy landscapes of acylphosphatase

L Yuan, H Sun, X Ma, Y Wang, Z Guo, X Qi, S Le… - Soft Matter, 2024 - pubs.rsc.org
Acylphosphatase (AcP) is an enzyme which catalyses the hydrolysis of acylphosphate. The
binding with the phosphate ion (Pi) assumes significance in preserving both the stability and …

Comparative analysis of folding and unfolding dynamics and free-energy landscapes in homologous cold shock proteins with variable thermal stabilities

Z Xue, H Sun, H Hong, Z Zhang, Y Zhang, Z Guo… - Physical Review …, 2024 - APS
Cold shock proteins from the mesophilic organism Bacillus subtilis (BsCSP), the
thermophilic organism Bacillus caldolyticus (BcCSP), and the hyperthermophilic organism …

Theoretical study of the nonlinear force-loading control in single-molecule stretching experiments

X Qi, Z Guo, S Le, H Chen - Communications in Theoretical …, 2024 - iopscience.iop.org
Force spectrum measurements with constant loading rates are widely used in single-
molecule manipulation experiments to study the mechanical stability and force response of …

Mutation in a Non-Force-Bearing Region of Protein L Influences Force-Dependent Unfolding Behavior

H Jiang, Y Wang, J Chen, D Hu, H Pan, Z Guo… - Chinese …, 2024 - iopscience.iop.org
Single-molecule magnetic tweezers (MT) have revealed multiple transition barriers along
the unfolding pathway of several two-state proteins, such as GB1 and Csp. In this study, we …