Abstract Model organism databases (MODs) have been collecting and integrating
biomedical research data for 30 years and were designed to meet specific needs of each …

Glucocerebrosidase (GBA1) mutations are associated with Gaucher disease (GD), an
autosomal recessive disorder caused by functional deficiency of glucocerebrosidase (GBA) …

Lysosomal storage disorders (LSDs) represent a complex and heterogeneous group of rare
genetic diseases due to mutations in genes coding for lysosomal enzymes, membrane …

With increasing socio-economic importance of the rare earth elements and yttrium (REY),
Norway has laid out plans for REY mining, from land-based to deep-sea mining, thereby …

Hydrogen sulfide (H 2 S) is a kind of gaseous signalling molecule that plays pivotal role in
various biological processes. So far, it is still a challenge to develop convenient and reliable …

A lysosome-targeted fluorescent chemodosimeter, 1, was developed for monitoring
endogenous and exogenous H2S by in vivo imaging of HeLa cells, D. melanogaster and C …

Genetic model systems allow researchers to probe and decipher aspects of human disease,
and animal models of disease are frequently specifically engineered and have been …

Intracellular accumulation of lipids and swollen dysfunctional lysosomes are linked to
several neurodegenerative diseases, including lysosomal storage disorders (LSD). Detailed …

Inborn errors of metabolism cause abnormal synthesis, recycling, or breakdown of amino
acids, neurotransmitters, and other various metabolites. This aberrant homeostasis …

Despite the unquestionable importance of the highly cationic feature of several small
polypeptides with high content of positively charged amino acids for their biological …