Form follows function: nanoparticle shape and its implications for nanomedicine

C Kinnear, TL Moore, L Rodriguez-Lorenzo… - Chemical …, 2017 - ACS Publications
This review is a comprehensive description of the past decade of research into
understanding how the geometry and size of nanoparticles affect their interaction with …

Converting nanotoxicity data to information using artificial intelligence and simulation

X Yan, T Yue, DA Winkler, Y Yin, H Zhu… - Chemical …, 2023 - ACS Publications
Decades of nanotoxicology research have generated extensive and diverse data sets.
However, data is not equal to information. The question is how to extract critical information …

Shape and orientation matter for the cellular uptake of nonspherical particles

S Dasgupta, T Auth, G Gompper - Nano letters, 2014 - ACS Publications
Recent advances in nanotechnology have made a whole zoo of particles of different shapes
available for applications, but their interaction with biological cells and their toxicity is often …

Curving cells inside and out: roles of BAR domain proteins in membrane sha** and its cellular implications

M Simunovic, E Evergren… - Annual review of cell …, 2019 - annualreviews.org
Many cellular processes rely on precise and timely deformation of the cell membrane. While
many proteins participate in membrane resha** and scission, usually in highly specialized …

Theoretical and computational investigations of nanoparticle–biomembrane interactions in cellular delivery

H Ding, Y Ma - Small, 2015 - Wiley Online Library
With the rapid development of nanotechnology, nanoparticles have been widely used in
many applications such as phototherapy, cell imaging, and drug/gene delivery. A better …

Mechanical force induces mitochondrial fission

SCJ Helle, Q Feng, MJ Aebersold, L Hirt, RR Grüter… - Elife, 2017 - elifesciences.org
Eukaryotic cells are densely packed with macromolecular complexes and intertwining
organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing …

Wrap** of nanoparticles by membranes

AH Bahrami, M Raatz, J Agudo-Canalejo… - Advances in colloid and …, 2014 - Elsevier
How nanoparticles interact with biomembranes is central for understanding their bioactivity.
Biomembranes wrap around nanoparticles if the adhesive interaction between the …

Critical particle sizes for the engulfment of nanoparticles by membranes and vesicles with bilayer asymmetry

J Agudo-Canalejo, R Lipowsky - ACS nano, 2015 - ACS Publications
The adhesion and engulfment of nanoparticles by biomembranes is essential for many
processes such as biomedical imaging, drug delivery, nanotoxicity, and viral infection. Many …

Membrane tension controls the assembly of curvature-generating proteins

M Simunovic, GA Voth - Nature communications, 2015 - nature.com
Abstract Proteins containing a Bin/Amphiphysin/Rvs (BAR) domain regulate membrane
curvature in the cell. Recent simulations have revealed that BAR proteins assemble into …

Linear aggregation of proteins on the membrane as a prelude to membrane remodeling

M Simunovic, A Srivastava… - Proceedings of the …, 2013 - National Acad Sciences
Adhesion and insertion of curvature-mediating proteins can induce dramatic structural
changes in cell membranes, allowing them to participate in several key cellular tasks. The …