Photocleavable Ortho-Nitrobenzyl-Protected DNA Architectures and Their Applications

MP O'Hagan, Z Duan, F Huang, S Laps, J Dong… - Chemical …, 2023 - ACS Publications
This review article introduces mechanistic aspects and applications of photochemically
deprotected ortho-nitrobenzyl (ONB)-functionalized nucleic acids and their impact on …

Therapeutic DNAzymes: from structure design to clinical applications

J Yan, M Ran, X Shen, H Zhang - Advanced Materials, 2023 - Wiley Online Library
Therapeutic DNAzymes have unceasingly intrigued the scientific community owing to their
prosperous gene regulation capability. The efficacy of DNAzymes against many types of …

Thermophoretic detection of exosomal microRNAs by nanoflares

J Zhao, C Liu, Y Li, Y Ma, J Deng, L Li… - Journal of the American …, 2020 - ACS Publications
Exosomal microRNAs (miRNAs) are reliable and noninvasive biomarkers for the early
diagnosis of cancer. Yet, accurate and feasible detection of exosomal miRNAs is often …

Cancer biomarker detection: recent achievements and challenges

L Wu, X Qu - Chemical Society Reviews, 2015 - pubs.rsc.org
The early detection of cancer can significantly reduce cancer mortality and saves lives. Thus,
a great deal of effort has been devoted to the exploration of new technologies to detect early …

Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy

HM Meng, H Liu, H Kuai, R Peng, L Mo… - Chemical Society …, 2016 - pubs.rsc.org
The combination of nanostructures with biomolecules leading to the generation of functional
nanosystems holds great promise for biotechnological and biomedical applications. As a …

Rationally engineered nucleic acid architectures for biosensing applications

M **ao, W Lai, T Man, B Chang, L Li… - Chemical …, 2019 - ACS Publications
Development of biosensing platforms plays a key role in research settings for identification
of biomarkers and in clinical applications for diagnostics. Biosensors based on nucleic acids …

Optochemical control of biological processes in cells and animals

N Ankenbruck, T Courtney, Y Naro… - Angewandte Chemie …, 2018 - Wiley Online Library
Biological processes are naturally regulated with high spatial and temporal control, as is
perhaps most evident in metazoan embryogenesis. Chemical tools have been extensively …

A NIR light gated DNA nanodevice for spatiotemporally controlled imaging of microRNA in cells and animals

J Zhao, H Chu, Y Zhao, Y Lu, L Li - Journal of the American …, 2019 - ACS Publications
Nanodevices have potential as intelligent sensing systems for detection of microRNAs
(miRNAs) in living cells. However, the resolution offered by “always active” nanodevices is …

Advancement of the emerging field of RNA nanotechnology

D Jasinski, F Haque, DW Binzel, P Guo - ACS nano, 2017 - ACS Publications
The field of RNA nanotechnology has advanced rapidly during the past decade. A variety of
programmable RNA nanoparticles with defined shape, size, and stoichiometry have been …

Organic dye assemblies with aggregation‐induced photophysical changes and their bio‐applications

C Ji, L Lai, P Li, Z Wu, W Cheng, M Yin - Aggregate, 2021 - Wiley Online Library
Phototheranostics provide a safe, effective, and noninvasive way for the diagnosis and
treatment of contemporary diseases, and organic dyes play a vital role. For example …