Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of
autoimmunity and the maintenance of immune homeostasis and represent a major barrier to …

Dendritic cells (DCs) play critical roles in activating innate immune cells and initiating
adaptive immune responses. The functions of DCs were originally obscured by their overlap …

Decades of work have elucidated cytokine signalling and transcriptional pathways that
control T cell differentiation and have led the way to targeted biologic therapies that are …

Specific microbial signals induce the differentiation of a distinct pool of RORγ+ regulatory T
(Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations …

Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to
their unique ability to initiate T cell responses and direct their differentiation into effector …

The brain is a site of relative immune privilege. Although CD4 T cells have been reported in
the central nervous system, their presence in the healthy brain remains controversial, and …

Obesity is a major risk factor for psoriasis, but how obesity disrupts the regulatory
mechanisms that keep skin inflammation in check is unclear. Here, we found that skin was …

Combined immunotherapy targeting the immune checkpoint receptors cytotoxic T-
lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1), or CTLA-4 …

CD4+ T regulatory cells (Treg) are central to immune homeostasis, their phenotypic
heterogeneity reflecting the diverse environments and target cells that they regulate. To …

Adaptive immune responses are tailored to different types of pathogens through
differentiation of naive CD4 T cells into functionally distinct subsets of effector T cells (T …