Abundant pleiotropy in human complex diseases and traits
S Sivakumaran, F Agakov, E Theodoratou… - The American Journal of …, 2011 - cell.com
We present a systematic review of pleiotropy among SNPs and genes reported to show
genome-wide association with common complex diseases and traits. We find abundant …
genome-wide association with common complex diseases and traits. We find abundant …
Prioritizing GWAS results: a review of statistical methods and recommendations for their application
Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most …
disease gene discovery. A substantial number of recent GWAS indicate that for most …
[HTML][HTML] Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context
Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality
control and have been linked to various diseases. Different views exist on the composition of …
control and have been linked to various diseases. Different views exist on the composition of …
[HTML][HTML] Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver
Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of disease states
ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic …
ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic …
[HTML][HTML] Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19
Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease …
essential to understand the immunopathogenesis and clinical course of coronavirus disease …
[HTML][HTML] Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause acute
respiratory disease and multiorgan failure. Finding human host factors that are essential for …
respiratory disease and multiorgan failure. Finding human host factors that are essential for …
Severe COVID-19 is marked by a dysregulated myeloid cell compartment
Summary Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract
infection, however, a subset of patients progress to severe disease and respiratory failure …
infection, however, a subset of patients progress to severe disease and respiratory failure …
A new genomic blueprint of the human gut microbiota
The composition of the human gut microbiota is linked to health and disease, but knowledge
of individual microbial species is needed to decipher their biological roles. Despite …
of individual microbial species is needed to decipher their biological roles. Despite …
[HTML][HTML] The short chain fatty acid butyrate imprints an antimicrobial program in macrophages
Host microbial cross-talk is essential to maintain intestinal homeostasis. However,
maladaptation of this response through microbial dysbiosis or defective host defense toward …
maladaptation of this response through microbial dysbiosis or defective host defense toward …
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …