Altered tissue mechanics and metabolism are defining characteristics of cancer that impact
not only proliferation but also migration. While migrating through a mechanically and …

Collective cancer invasion with leader–follower organization is increasingly recognized as a
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …

Abstract Glucose transporter 1 (GLUT1) overexpression in tumor cells is a potential target for
drug therapy, but few studies have reported screening GLUT1 inhibitors from natural or …

Abstract Background Circular RNAs (circRNAs) are widely expressed in human cells and
are closely associated with cancer development. However, they have rarely been …

Cancer cells face various metabolic challenges during tumor progression, including growth
in the nutrient-altered and oxygen-deficient microenvironment of the primary site …

Energy deprivation is a frequent adverse event in tumors that is caused by mutations,
malperfusion, hypoxia, and nutrition deficit. The resulting bioenergetic stress leads to …

Objective The sodium-glucose transporter 2 (SGLT2) inhibitors Canagliflozin and
Dapagliflozin are recently approved medications for type 2 diabetes. Recent studies indicate …

Metabolic reprogramming is a hallmark of cancer metastasis in which cancer cells
manipulate their metabolic profile to meet the dynamic energetic requirements of the tumor …

Metastatic dissemination has lethal consequences for cancer patients. Accruing evidence
supports the hypothesis that tumor cells can migrate and metastasize as clusters of cells …

Glucose and lactate play important roles for tumor growth. How to simultaneously deprive
tumors of glucose and lactate is a big challenge. We have developed a cascade catalytic …