Genetically encoded biosensors are the vital components of synthetic biology and metabolic
engineering, as they are regarded as powerful devices for the dynamic control of genotype …

DNA and RNA sequencing technologies have revolutionized biology and biomedical
sciences, sequencing full genomes and transcriptomes at very high speeds and reasonably …

Lignin-derived mixtures intended for bioconversion commonly contain high concentrations
of aromatic acids, aliphatic acids, and salts. The inherent toxicity of these chemicals places a …

Microbial response to toxic fluoride anion has traditionally been studied by adding inorganic
fluoride salts to growth media. Fluoride is known to spontaneously transit the membrane as …

Abstract Machine learning applied to large compendia of transcriptomic data has enabled
the decomposition of bacterial transcriptomes to identify independently modulated sets of …

Vibrio natriegens regulates natural competence through the TfoX and QstR transcription
factors, which are involved in external DNA capture and transport. However, the extensive …

Biological conversion of lignin from biomass offers a promising strategy for sustainable
production of fuels and chemicals. However, aromatic compounds derived from lignin …

Transcriptomic data is accumulating rapidly; thus, scalable methods for extracting
knowledge from this data are critical. Here, we assembled a top-down expression and …

Relationships between the genome, transcriptome, and metabolome underlie all evolved
phenotypes. However, it has proved difficult to elucidate these relationships because of the …

Public gene expression databases are a rapidly expanding resource of organism responses
to diverse perturbations, presenting both an opportunity and a challenge for bioinformatics …