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The spread, treatment, and prevention of HIV-1: evolution of a global pandemic
The most up-to-date estimates demonstrate very heterogeneous spread of HIV-1, and more
than 30 million people are now living with HIV-1 infection, most of them in sub-Saharan …
than 30 million people are now living with HIV-1 infection, most of them in sub-Saharan …
The antibody response against HIV-1
Neutralizing antibodies (NAbs) typically play a key role in controlling viral infections and
contribute to the protective effect of many successful vaccines. In the case of HIV-1 infection …
contribute to the protective effect of many successful vaccines. In the case of HIV-1 infection …
Immune-correlates analysis of an HIV-1 vaccine efficacy trial
Background In the RV144 trial, the estimated efficacy of a vaccine regimen against human
immunodeficiency virus type 1 (HIV-1) was 31.2%. We performed a case–control analysis to …
immunodeficiency virus type 1 (HIV-1) was 31.2%. We performed a case–control analysis to …
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
S Rerks-Ngarm, P Pitisuttithum… - … England Journal of …, 2009 - Mass Medical Soc
Background The development of a safe and effective vaccine against the human
immunodeficiency virus type 1 (HIV-1) is critical to pandemic control. Methods In a …
immunodeficiency virus type 1 (HIV-1) is critical to pandemic control. Methods In a …
Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy
Antiretroviral drug therapy (ART) effectively suppresses replication of both the
immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon …
immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon …
HIV-specific antibodies capable of ADCC are common in breastmilk and are associated with reduced risk of transmission in women with high viral loads
There are limited data describing the functional characteristics of HIV-1 specific antibodies in
breast milk (BM) and their role in breastfeeding transmission. The ability of BM antibodies to …
breast milk (BM) and their role in breastfeeding transmission. The ability of BM antibodies to …
Antibody Fc effector functions and IgG3 associate with decreased HIV-1 risk
HVTN 505 is a preventative vaccine efficacy trial testing DNA followed by recombinant
adenovirus serotype 5 (rAd5) in circumcised, Ad5-seronegative men and transgendered …
adenovirus serotype 5 (rAd5) in circumcised, Ad5-seronegative men and transgendered …
Lessons from the RV144 Thai phase III HIV-1 vaccine trial and the search for correlates of protection
RV144 remains the only HIV-1 vaccine trial to demonstrate efficacy against HIV-1
acquisition. The prespecified analysis of immune correlates of risk showed that antibodies …
acquisition. The prespecified analysis of immune correlates of risk showed that antibodies …
Single-chain soluble BG505. SOSIP gp140 trimers as structural and antigenic mimics of mature closed HIV-1 Env
Similar to other type I fusion machines, the HIV-1 envelope glycoprotein (Env) requires
proteolytic activation; specifically, cleavage of a gp160 precursor into gp120 and gp41 …
proteolytic activation; specifically, cleavage of a gp160 precursor into gp120 and gp41 …
Progress in HIV vaccine development
DC Hsu, RJ O'Connell - Human vaccines & immunotherapeutics, 2017 - Taylor & Francis
An HIV-1 vaccine is needed to curtail the HIV epidemic. Only one (RV144) out of the 6 HIV-1
vaccine efficacy trials performed showed efficacy. A potential mechanism of protection is the …
vaccine efficacy trials performed showed efficacy. A potential mechanism of protection is the …