Abstract “Everyday” exposures in the neonatal period, such as pain, may impact brain health
in preterm infants. Specifically, greater exposure to painful procedures in the initial weeks …

Critically ill newborns experience numerous painful procedures as part of lifesaving care in
the Neonatal Intensive Care Unit. However, painful exposures in the neonatal period have …

Aim To investigate the impact of the level of pain experienced by infants born preterm on
neurodevelopmental outcomes during their stay in a neonatal intensive care unit. Method In …

Background We assessed variability of analgesic use across three tertiary neonatal
intensive care units (NICUs) accounting for early-life pain, quantified as number of invasive …

This systematic review and meta-analysis aimed to investigate the association of neonatal
exposure to pain, stress, opiate administration alone, as well as opiate administration prior …

Preterm infants are more likely to be born with congenital anomalies than those who are
born at full-term. Conversely, neonates born with congenital anomalies are also more likely …

Very preterm (VPT) infants requiring hospitalization in the Neonatal Intensive Care Unit
(NICU) are exposed to several stressful procedural experiences. One consequence of NICU …

Chronic pain is highly prevalent in the pediatric population. Many factors are involved in the
transition from acute to chronic pain. Currently, there are conceptual models proposed, but …

Background Data on preschool neurodevelopment of preterm infants according to the
duration of their neonatal exposure to opioids with/without midazolam is limited. We aimed …

Background Preterm infants often require mechanical ventilation (MV), which can be a
painful experience. Opioids (such as morphine) are used to provide analgesia, despite …