Photosensitizers-loaded nanocarriers for enhancement of photodynamic therapy in melanoma treatment

AM Udrea, A Smarandache, A Dinache, C Mares… - Pharmaceutics, 2023 - mdpi.com
Malignant melanoma poses a significant global health burden. It is the most aggressive and
lethal form of skin cancer, attributed to various risk factors such as UV radiation exposure …

Synthesis and evaluation of novel meso-substitutedphenyl dithieno [3, 2-b] thiophene-fused BODIPY derivatives as efficient photosensitizers for photodynamic therapy

N Cao, Y Jiang, ZB Song, D Chen, D Wu… - European Journal of …, 2024 - Elsevier
The discovery of new photosensitizer drugs with long wavelength Uv–vis absorption, high
efficiency and low side-effects is still a challenge in photodynamic therapy. Here a series of …

Towards machine learning-based quantitative hyperspectral image guidance for brain tumor resection

D Black, D Byrne, A Walke, S Liu, A Di Ieva… - Communications …, 2024 - nature.com
Background Complete resection of malignant gliomas is hampered by the difficulty in
distinguishing tumor cells at the infiltration zone. Fluorescence guidance with 5-ALA assists …

Challenges in, and recommendations for, hyperspectral imaging in ex vivo malignant glioma biopsy measurements

A Walke, D Black, PA Valdes, W Stummer, S König… - Scientific reports, 2023 - nature.com
The visualization of protoporphyrin IX (PPIX) fluorescence with the help of surgical
microscopes during 5-aminolevulinic acid-mediated fluorescence-guided resection (FGR) of …

Pharmaceutical applications of molecular tweezers, clefts and clips

A Mbarek, G Moussa, J Leblond Chain - Molecules, 2019 - mdpi.com
Synthetic acyclic receptors, composed of two arms connected with a spacer enabling
molecular recognition, have been intensively explored in host-guest chemistry in the past …

Predictors and limitations of the penetration depth of photodynamic effects in the rodent brain

CT Inglut, B Gaitan, D Najafali, IA Lopez… - Photochemistry and …, 2020 - Wiley Online Library
Fluorescence‐guided surgery (FGS) is routinely utilized in clinical centers around the world,
whereas the combination of FGS and photodynamic therapy (PDT) has yet to reach clinical …

Protoporphyrin IX in serum of high-grade glioma patients: A novel target for disease monitoring via liquid biopsy

A Walke, C Krone, W Stummer, S König… - Scientific Reports, 2024 - nature.com
High-grade gliomas (HGG) carry a dismal prognosis. Diagnosis comprises MRI followed by
histopathological evaluation of tissue; no blood biomarker is available. Patients are …

The potential of 5-aminolevulinic acid as a contrast agent in MR imaging: challenges and opportunities

A Ebrahimpour, N Riahi Alam… - Journal of Sciences …, 2021 - jsciences.ut.ac.ir
Nowadays, 5-aminolevulinic acid (5-ALA) plays an influential role in the detection of
malignant tumors as a photodynamic diagnosis tool. Nevertheless, an outlook regarding 5 …

Ciprofloxacin enhances phototoxicity of 5-aminolevulinic acid mediated photodynamic treatment for chordoma cell lines

HH Gull, C Karadag, B Senger, RV Sorg… - Photodiagnosis and …, 2021 - Elsevier
Background: Chordoma are uncommon aggressive tumors of the skeleton. Surgical
resection is often subtotal and adjuvant treatment possibilities are limited as chordomas are …

[PDF][PDF] 5-aminolevulinic acid: an emerging signaling molecule involved in improving abiotic stress tolerance in plants.

D Gupta, SM Prasad - Biochemical & Cellular Archives, 2020 - researchgate.net
It has been perceived, that approximately 70% of the crop harvest is halt by the
environmental stressors. The climatic variations like ultraviolet radiations, alternate …