Inflammation contributes to the pathogenesis of several diseases. Fenofibrate, known as a
peroxisome proliferator-activated receptor-α (PPAR-α) agonist, is a classic drug for treating …

The inclusion of women in preclinical pain studies has become more commonplace in the
last decade as the National Institutes of Health (NIH) released its “Sex as a Biological …

Introduction Stroke is a disease that presents with well-known sex differences. While women
account for more stroke deaths, recent data show that after adjusting for age and pre-stroke …

Microglia are the principle immune cells of the brain. Once activated, microglial cells may
exhibit a wide repertoire of the context-dependent profiles ranging from highly neurotoxic to …

Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Mutations in genes
encoding proteins involved in amyloid-β peptide (Aβ) production are responsible for …

Chia is a good source of calcium, however it is not been previously reported its
bioavailability associated with an inflammatory condition. Thus, the present study evaluated …

One area of microglial biology that has been relatively neglected until recently is sex
differences and this is in spite of the fact that sex is a risk factor in several diseases that are …

Premenopausal women and intact female rodents sustain smaller cerebral infarctions than
males. Several sex-dependent differences have been identified as potential contributors, but …

Targeting peroxisome proliferator-activated receptors (PPARs) has received increasing
interest as a potential strategy to treat substance use disorders due to the localization of …

Time-of-day significantly influences the severity and incidence of stroke. Evidence has
emerged not only for circadian governance over stroke risk factors, but also for important …