Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

Over the past decades, the bulk of chemists' interests have been on heterocyclic compounds
and their various derivatives as well as their applications in the pharmaceutical and …

Carbonic anhydrases (CAs), a group of ubiquitously expressed metalloenzymes, are
involved in numerous physiological and pathological processes, including …

The mitochondrial isoforms VA/VB of metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1)
are involved in metabolic processes, such as de novo lipogenesis and fatty acid …

Many compounds containing a five‐membered heterocyclic ring display exceptional
chemical properties and versatile biological activities. In this Minireview, thiadiazoles are …

The primary physiological process of respiration produces carbon dioxide (CO 2) that reacts
with water molecules which subsequently liberates bicarbonate (HCO–3) and protons …

Neisseria gonorrhoeae is an urgent threat to public health in the United States and around
the world. Many of the current classes of antibiotics to treat N. gonorrhoeae infection are …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are a family of metalloenzymes that catalyze the
reversible interconversion of CO2 and HCO3−. Of the 15 isoforms of human (h) α-CA, 12 are …

Molecules containing the sulfonamide group (R-SO2NH2) as well as its structurally related
isosters, sulfamido (R-NH-SO2NH2) and sulfamato (RO-SO2NH2), constitute the most …

Introduction: An epileptic seizure is a transient occurrence of signs and/or symptoms due to
abnormal excessive or synchronous neuronal activity in the brain. The International League …