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Research priorities for an HIV cure: international AIDS society global scientific strategy 2021
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses
HIV-1-infected cells that persist despite antiretroviral therapy (ART) are frequently
considered" transcriptionally silent," but active viral gene expression may occur in some …
considered" transcriptionally silent," but active viral gene expression may occur in some …
Prolonged viral suppression with anti-HIV-1 antibody therapy
C Gaebler, L Nogueira, E Stoffel, TY Oliveira, G Breton… - Nature, 2022 - nature.com
HIV-1 infection remains a public health problem with no cure. Anti-retroviral therapy (ART) is
effective but requires lifelong drug administration owing to a stable reservoir of latent …
effective but requires lifelong drug administration owing to a stable reservoir of latent …
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
NF McMyn, J Varriale, EJ Fray, C Zitzmann… - The Journal of clinical …, 2023 - jci.org
HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
KM Bruner, Z Wang, FR Simonetti, AM Bender… - Nature, 2019 - nature.com
A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure,–.
Curative strategies that target the reservoir are being tested, and require accurate, scalable …
Curative strategies that target the reservoir are being tested, and require accurate, scalable …
Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
JA White, F Wu, S Yasin, M Moskovljevic… - The Journal of clinical …, 2023 - jci.org
Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below
the detection limit of clinical assays. However, some individuals experience persistent …
the detection limit of clinical assays. However, some individuals experience persistent …
[HTML][HTML] Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones
JA Collora, R Liu, D Pinto-Santini, N Ravindra… - Immunity, 2022 - cell.com
Understanding the drivers and markers of clonally expanding HIV-1-infected CD4+ T cells is
essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface …
essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface …
Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4+ and CD8+ T cells
M Dubé, O Tastet, C Dufour, G Sannier, N Brassard… - Cell host & …, 2023 - cell.com
Spontaneous transcription and translation of HIV can persist during suppressive
antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this …
antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this …
Combination therapy with anti-HIV-1 antibodies maintains viral suppression
Individuals infected with HIV-1 require lifelong antiretroviral therapy, because interruption of
treatment leads to rapid rebound viraemia. Here we report on a phase 1b clinical trial in …
treatment leads to rapid rebound viraemia. Here we report on a phase 1b clinical trial in …