Unitary models of meiotic recombination postulate that a central intermediate containing
Holliday junctions is resolved to generate either noncrossover or crossover recombinants …

We identify a novel meiotic recombination intermediate, the single-end invasion (SEI), which
occurs during the transition from double-strand breaks (DSBs) to double-Holliday junction …

Homologous recombination safeguards genome integrity, but it can also cause genome
instability of important consequences for cell proliferation and organism development …

The BLM helicase has been shown to maintain genome stability by preventing accumulation
of aberrant recombination intermediates. We show here that the Saccharomyces cerevisiae …

Template switching (TS) mediates damage bypass via a recombination-related mechanism
involving PCNA polyubiquitination and polymerase δ–dependent DNA synthesis. Using two …

Recombination between homologous chromosomes of different parental origin (homologs)
is necessary for their accurate segregation during meiosis. It has been suggested that …

Summary The topoisomerase III (Top3)-Rmi1 heterodimer, which catalyzes DNA single-
strand passage, forms a conserved complex with the Bloom's helicase (BLM, Sgs1 in …

Crossover recombination is essential for homolog segregation during meiosis. In contrast to
spontaneous mitotic recombination, meiotic recombination is intrinsic being initiated by the …

Background Biofilms are a highly structured consortia of microorganisms that adhere to a
substrate and are encased within an extracellular matrix (ECM) that is produced by the …

Budding yeast lacking the Sgs1 helicase and the Mus81/Mms4 endonuclease are inviable,
and indirect studies implicate homologous recombination gone awry as the cause of death …