Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids
between the different compartments of eukaryotic cells. They act by recruiting and/or …

Designing an RNA-interacting molecule that displays high therapeutic efficacy while
retaining specificity within a broad concentration range remains a challenging task …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

VPS34 phosphorylates phosphatidylinositol to produce PtdIns3P and is the progenitor of the
phosphoinositide 3-kinase (PI3K) family. VPS34 has a simpler domain organization than …

Cilia are hair-like projections found on almost all cells in the human body. Originally
believed to function merely in motility, the function of solitary non-motile (primary) cilia was …

Studies of human genetic disorders have traditionally followed a reductionist paradigm.
Traits are defined as Mendelian or complex based on family pedigree and population data …

Autophagy is a process through which intracellular cargoes are catabolised inside
lysosomes. It involves the formation of autophagosomes initiated by the serine/threonine …

The jasmonate (JA)-pathway regulators MYC2, MYC3, and MYC4 are central nodes in plant
signaling networks integrating environmental and developmental signals to fine-tune JA …

Purpose: We studied the impact of mTOR signaling inhibition with rapamycin in head and
neck squamous cell carcinoma (HNSCC) in the neoadjuvant setting. The goals were to …