Artificial intelligence-driven advances in protein structure prediction in recent years have
raised the question: has the protein structure-prediction problem been solved? Here, with a …

A 'principles and practice'tutorial-style review of the application of solution-phase NMR in the
analysis of the mechanisms of homogeneous organic and organometallic reactions and …

Paramagnetic centers in biomolecules, such as specific metal ions that are bound to a
protein, affect the nuclei in their surrounding in various ways. One of these effects is the …

The fluorine-19 nucleus was recognized early to harbor exceptional properties for NMR
spectroscopy. With 100% natural abundance, a high gyromagnetic ratio (83% sensitivity …

Methyl-specific isotope labeling is a powerful tool to study the structure, dynamics and
interactions of large proteins and protein complexes by solution-state NMR. However …

Thanks to magic-angle spinning (MAS) probes with frequencies of 60–100 kHz, the benefit
of high-sensitivity 1H detection can now be broadly realized in biomolecular solid-state NMR …

Protein nuclear magnetic resonance (NMR) spectroscopy relies on the ability to isotopically
label polypeptides, which is achieved through heterologous expression in various host …

G protein-coupled receptors (GPCRs) are involved in a multitude of cellular signaling
cascades and consequently are a prominent target for pharmaceutical drugs. In the past …

As structural biology trends towards larger and more complex biomolecular targets, a
detailed understanding of their interactions and underlying structures and dynamics is …

To date, in-cell NMR has elucidated various aspects of protein behaviour by associating
structures in physiological conditions. Meanwhile, current studies of this method mostly have …