In this review, the history of boron's early use in drugs, and the history of the use of boron
functional groups in medicinal chemistry applications are discussed. This includes …

Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a
variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In …

Bioconjugates are multifunctional constructs in which biomolecules like peptides, proteins,
vitamins and nucleic acids are endowed with the properties of specific payloads. These …

Efficient cellular delivery of biologically active molecules is one of the key factors that affect
the discovery and development of novel drugs. The plasma membrane is the first barrier that …

The presence of a mucus layer that covers the surface of a variety of organs has been
capitalized to develop mucoadhesive dosage forms that remain in the administration site for …

The world is made up of fundamental elements, ions and molecules that continuously
interact with each other through a series of chemical reactions. Thus, it is important to have a …

Boron containing compounds have not been widely studied in Medicinal Chemistry, mainly
due to the idea that this group could confer some toxicity. Nowadays, this concept has been …

Conspectus Delivery remains a major obstacle restricting the potential action of small
molecular drugs as well as novel biologics which cannot readily enter cells without the help …

Messenger RNA (mRNA) transfection is the prerequisite for the application of mRNA‐based
therapeutics. In hard‐to‐transfect cells, such as macrophages, the effective transfection of …

This review summarizes the use of orthogonal dynamic covalent bonds to build functional
systems. Dynamic covalent bonds are unique because of their dual nature. They can be as …