Considerable progress has been made in understanding the function of alveolar epithelial
cells in a quiescent state and regeneration mechanism after lung injury. Lung injury occurs …

Interstitial lung diseases (ILDs) that are known as diffuse parenchymal lung diseases
(DPLDs) lead to the damage of alveolar epithelium and lung parenchyma, culminating in …

Severe viral pneumonia can induce rapid expansion of KRT5+ basal-like cells in small
airways and alveoli; this forms a scar-like structure that persists in the injured alveoli and …

Alveolar type II (ATII) cells are progenitors in alveoli and can repair the alveolar epithelium
after injury. They are intertwined with the microenvironment for alveolar epithelial cell …

The lung's gas exchange surface is comprised of alveolar AT1 and AT2 cells that are
corrupted in several common and deadly diseases. They arise from a bipotent progenitor …

Although tissue homeostasis—the steady state—implies stability, our organs are in a state of
continual, large-scale cellular flux. This flux underpins an organ's ability to homeostatically …

Engineered whole lungs may one day expand therapeutic options for patients with end-
stage lung disease. However, the feasibility of ex vivo lung regeneration remains limited by …

The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of
unprecedented research efforts to understand the pathogenesis mediated by Severe Acute …

The lung is the most critical organ of the respiratory system supporting gas exchange.
Constant interaction with the external environment makes the lung vulnerable to injury …

Clinical and molecular heterogeneity are common features of human disease.
Understanding the basis for heterogeneity has led to major advances in therapy for many …