Lineage studies conducted in the retina more than 25 years ago demonstrated the
multipotency of retinal progenitor cells (RPCs). The number and types of cells produced by …

The vertebrate retina is a well-characterized and tractable model for studying neurogenesis.
Retinal neurons and glia are generated in a conserved sequence from a pool of multipotent …

Multipotent retinal progenitors undergo a varied number of divisions to produce clones of
heterogeneous sizes and cell types. We describe the transition from a proliferating …

HMGA (high mobility group A)(HMGA1 and HMGA2) are small non-histone proteins that can
bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors …

The development of complex tissues requires that mitotic progenitor cells integrate
information from the environment. The highly varied outcomes of such integration processes …

Cell identity is acquired in different brain structures according to a stereotyped timing
schedule, by accommodating the proliferation of multipotent progenitor cells and the …

Continuous neurogenesis in the adult nervous system requires a delicate balance between
proliferation and differentiation. Although Wnt/β-catenin and Hedgehog signalling pathways …

The homeodomain protein, Otx2, is a critical regulator of vertebrate photoreceptor genesis.
However, the genetic elements that define the expression of Otx2 during photoreceptor …

Retinal development is under the coordinated control of overlap** networks of signaling
pathways and transcription factors. The paper was conceived as a review of the data and …

Background Dynamic monitoring of protein expression and localization is fundamental to the
understanding of biological processes. The paired-class homeodomain-containing …