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Radiochemistry for positron emission tomography
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …
Mechanisms of ADC toxicity and strategies to increase ADC tolerability
Simple Summary Antibody-drug conjugates (ADC) are a rapidly expanding class of anti-
cancer drugs, with twelve agents in current clinical use. Despite recent successes, many …
cancer drugs, with twelve agents in current clinical use. Despite recent successes, many …
[HTML][HTML] Antibody–drug conjugates: A review of approved drugs and their clinical level of evidence
Simple Summary Antibody–drug conjugates (ADC) have shown remarkable therapeutic
activity in a wide range of hematologic and solid tumors. Herein, we discuss the …
activity in a wide range of hematologic and solid tumors. Herein, we discuss the …
Antibody–drug conjugates: a comprehensive review
P Khongorzul, CJ Ling, FU Khan… - Molecular Cancer …, 2020 - aacrjournals.org
Antibody–drug conjugates (ADC) are one of the fastest growing anticancer drugs. This
approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that …
approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that …
Antibody–drug conjugates for cancer
CH Chau, PS Steeg, WD Figg - The Lancet, 2019 - thelancet.com
Antibody–drug conjugates (ADCs) are immunoconjugates comprised of a monoclonal
antibody tethered to a cytotoxic drug (known as the payload) via a chemical linker. The ADC …
antibody tethered to a cytotoxic drug (known as the payload) via a chemical linker. The ADC …
A comprehensive overview on antibody-drug conjugates: from the conceptualization to cancer therapy
F Riccardi, M Dal Bo, P Macor, G Toffoli - Frontiers in Pharmacology, 2023 - frontiersin.org
Antibody-Drug Conjugates (ADCs) represent an innovative class of potent anti-cancer
compounds that are widely used in the treatment of hematologic malignancies and solid …
compounds that are widely used in the treatment of hematologic malignancies and solid …
Cleavable linkers in antibody–drug conjugates
JD Bargh, A Isidro-Llobet, JS Parker… - Chemical Society …, 2019 - pubs.rsc.org
Antibody–Drug Conjugates (ADCs) are now established as a major class of therapeutics for
the clinical treatment of cancer. The properties of the linker between the antibody and the …
the clinical treatment of cancer. The properties of the linker between the antibody and the …
Antibody-drug conjugates in lung cancer: dawn of a new era?
Antibody-drug conjugates (ADCs) are one of fastest growing classes of oncology drugs in
modern drug development. By harnessing the powers of both cytotoxic chemotherapy and …
modern drug development. By harnessing the powers of both cytotoxic chemotherapy and …
Antibody–drug conjugates—a tutorial review
Antibody–drug conjugates (ADCs) are a family of targeted therapeutic agents for the
treatment of cancer. ADC development is a rapidly expanding field of research, with over 80 …
treatment of cancer. ADC development is a rapidly expanding field of research, with over 80 …
Potential of antibody–drug conjugates (ADCs) for cancer therapy
The primary purpose of ADCs is to increase the efficacy of anticancer medications by
minimizing systemic drug distribution and targeting specific cells. Antibody conjugates …
minimizing systemic drug distribution and targeting specific cells. Antibody conjugates …