Radiochemistry for positron emission tomography

J Rong, A Haider, TE Jeppesen, L Josephson… - Nature …, 2023 - nature.com
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

Mechanisms of ADC toxicity and strategies to increase ADC tolerability

TD Nguyen, BM Bordeau, JP Balthasar - Cancers, 2023 - mdpi.com
Simple Summary Antibody-drug conjugates (ADC) are a rapidly expanding class of anti-
cancer drugs, with twelve agents in current clinical use. Despite recent successes, many …

[HTML][HTML] Antibody–drug conjugates: A review of approved drugs and their clinical level of evidence

P Gogia, H Ashraf, S Bhasin, Y Xu - Cancers, 2023 - mdpi.com
Simple Summary Antibody–drug conjugates (ADC) have shown remarkable therapeutic
activity in a wide range of hematologic and solid tumors. Herein, we discuss the …

Antibody–drug conjugates: a comprehensive review

P Khongorzul, CJ Ling, FU Khan… - Molecular Cancer …, 2020 - aacrjournals.org
Antibody–drug conjugates (ADC) are one of the fastest growing anticancer drugs. This
approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that …

Antibody–drug conjugates for cancer

CH Chau, PS Steeg, WD Figg - The Lancet, 2019 - thelancet.com
Antibody–drug conjugates (ADCs) are immunoconjugates comprised of a monoclonal
antibody tethered to a cytotoxic drug (known as the payload) via a chemical linker. The ADC …

A comprehensive overview on antibody-drug conjugates: from the conceptualization to cancer therapy

F Riccardi, M Dal Bo, P Macor, G Toffoli - Frontiers in Pharmacology, 2023 - frontiersin.org
Antibody-Drug Conjugates (ADCs) represent an innovative class of potent anti-cancer
compounds that are widely used in the treatment of hematologic malignancies and solid …

Cleavable linkers in antibody–drug conjugates

JD Bargh, A Isidro-Llobet, JS Parker… - Chemical Society …, 2019 - pubs.rsc.org
Antibody–Drug Conjugates (ADCs) are now established as a major class of therapeutics for
the clinical treatment of cancer. The properties of the linker between the antibody and the …

Antibody-drug conjugates in lung cancer: dawn of a new era?

N Coleman, TA Yap, JV Heymach… - npj Precision …, 2023 - nature.com
Antibody-drug conjugates (ADCs) are one of fastest growing classes of oncology drugs in
modern drug development. By harnessing the powers of both cytotoxic chemotherapy and …

Antibody–drug conjugates—a tutorial review

S Baah, M Laws, KM Rahman - Molecules, 2021 - mdpi.com
Antibody–drug conjugates (ADCs) are a family of targeted therapeutic agents for the
treatment of cancer. ADC development is a rapidly expanding field of research, with over 80 …

Potential of antibody–drug conjugates (ADCs) for cancer therapy

HE Marei, C Cenciarelli, A Hasan - Cancer Cell International, 2022 - Springer
The primary purpose of ADCs is to increase the efficacy of anticancer medications by
minimizing systemic drug distribution and targeting specific cells. Antibody conjugates …