All preclinical procedures for analgesic drug discovery involve two components: 1) a “pain
stimulus”(the principal independent variable), which is delivered to an experimental subject …

Neuronal precursor cells extend multiple neurites during development, one of which extends
to form an axon whereas others develop into dendrites. Chemical stimulation of N-methyl D …

The delivery of a nerve insult (a “conditioning lesion”) prior to a subsequent test lesion
increases the number of regenerating axons and accelerates the speed of regeneration from …

Pain is often associated with depression of behavior and mood, and relief of pain-related
depression is a common goal of treatment. This study tested the hypothesis that pain-related …

To facilitate polarized vesicular trafficking and signal transduction, neuronal endosomes
have evolved sophisticated mechanisms for pH homeostasis. NHE5 is a member of the …

Organic devices are attracting considerable attention as prostheses for the recovery of
retinal light sensitivity lost to retinal degenerative disease. The biotic/abiotic interface …

Pain-related depression of behavior and mood is a key therapeutic target in the treatment of
pain. Clinical evidence suggests a role for decreased dopamine (DA) signaling in pain …

Electroceuticals are emerging as complementary or as an alternative to traditional interests
in nanomedicine that mainly focus on exploiting nanomaterials for drug delivery. Although …

To develop treatments for neurodegenerative disorders, it is critical to understand the
biology and function of neurons in both normal and diseased states. Molecular studies of …

Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent, progressive and often
irreversible syndrome which causes chronic pain and poor quality of life in patients …