Factors affecting the clearance and biodistribution of polymeric nanoparticles
F Alexis, E Pridgen, LK Molnar… - Molecular …, 2008 - ACS Publications
Nanoparticle (NP) drug delivery systems (5− 250 nm) have the potential to improve current
disease therapies because of their ability to overcome multiple biological barriers and …
disease therapies because of their ability to overcome multiple biological barriers and …
Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
DE Owens III, NA Peppas - International journal of pharmaceutics, 2006 - Elsevier
The process of opsonization is one of the most important biological barriers to controlled
drug delivery. Injectable polymeric nanoparticle carriers have the ability to revolutionize …
drug delivery. Injectable polymeric nanoparticle carriers have the ability to revolutionize …
Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake
Delivery and toxicity are critical issues facing nanomedicine research. Currently, there is
limited understanding and connection between the physicochemical properties of a …
limited understanding and connection between the physicochemical properties of a …
Polymer-based nanocapsules for drug delivery
CE Mora-Huertas, H Fessi, A Elaissari - International journal of …, 2010 - Elsevier
A review of the state of knowledge on nanocapsules prepared from preformed polymers as
active substances carriers is presented. This entails a general review of the different …
active substances carriers is presented. This entails a general review of the different …
Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties
SM Moghimi, J Szebeni - Progress in lipid research, 2003 - Elsevier
This article critically examines and evaluates the likely mechanisms that contribute to
prolonged circulation times of sterically protected nanoparticles and liposomes. It is …
prolonged circulation times of sterically protected nanoparticles and liposomes. It is …
Nanoparticles for drug delivery: the need for precision in reporting particle size parameters
M Gaumet, A Vargas, R Gurny, F Delie - European journal of …, 2008 - Elsevier
Polymeric drug-loaded nanoparticles have been extensively studied in the field of drug
delivery. Biodistribution depends on the physicochemical properties of particles, especially …
delivery. Biodistribution depends on the physicochemical properties of particles, especially …
Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery
N Nishiyama, K Kataoka - Pharmacology & therapeutics, 2006 - Elsevier
Polymeric micelles, self-assemblies of block copolymers, are promising nanocarrier systems
for drug and gene delivery. Until now, several micellar formulations of antitumor drugs have …
for drug and gene delivery. Until now, several micellar formulations of antitumor drugs have …
Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering
Regenerative engineering converges tissue engineering, advanced materials science, stem
cell science, and developmental biology to regenerate complex tissues such as whole limbs …
cell science, and developmental biology to regenerate complex tissues such as whole limbs …
Chemical basis of interactions between engineered nanoparticles and biological systems
As defined by the European Commission, a nanomaterial is a natural, an incidental, or a
manufactured material containing particles in an unbound state or as an aggregate or …
manufactured material containing particles in an unbound state or as an aggregate or …
Antibiofouling polymer interfaces: poly (ethylene glycol) and other promising candidates
Nonspecific protein adsorption and/or microbial adsorption on biomedical materials
adversely affects the efficacy of a range of biomedical systems, from implants and …
adversely affects the efficacy of a range of biomedical systems, from implants and …