Polymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes
Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …
Current update on intrinsic and acquired colistin resistance mechanisms in bacteria
Colistin regained global interest as a consequence of the rising prevalence of multidrug-
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …
The global distribution and spread of the mobilized colistin resistance gene mcr-1
Colistin represents one of the few available drugs for treating infections caused by
carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of …
carbapenem-resistant Enterobacteriaceae. As such, the recent plasmid-mediated spread of …
[HTML][HTML] Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?
M Exner, S Bhattacharya, B Christiansen… - GMS hygiene and …, 2017 - ncbi.nlm.nih.gov
In the past years infections caused by multidrug-resistant Gram-negative bacteria have
dramatically increased in all parts of the world. This consensus paper is based on …
dramatically increased in all parts of the world. This consensus paper is based on …
Next-generation approaches to understand and combat the antibiotic resistome
Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …
Towards understanding MCR-like colistin resistance
J Sun, H Zhang, YH Liu, Y Feng - Trends in microbiology, 2018 - cell.com
Antibiotic resistance has become a global public health priority. Polymyxins, a family of
cationic polypeptide antibiotics, act as a final line of refuge against severe infections by …
cationic polypeptide antibiotics, act as a final line of refuge against severe infections by …
Molecular mechanisms related to colistin resistance in Enterobacteriaceae
Colistin is an effective antibiotic for treatment of most multidrug-resistant Gram-negative
bacteria. It is used currently as a last-line drug for infections due to severe Gram-negative …
bacteria. It is used currently as a last-line drug for infections due to severe Gram-negative …
The rapid spread of carbapenem-resistant Enterobacteriaceae
Carbapenems, our one-time silver bullet for multidrug resistant bacterial infections, are now
threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae …
threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae …
Molecular mechanisms of polymyxin resistance: knowns and unknowns
Colistin, also referred to as polymyxin E, is an effective antibiotic against most multidrug-
resistant Gram-negative bacteria and is currently used as a last-line drug for treating severe …
resistant Gram-negative bacteria and is currently used as a last-line drug for treating severe …
Alternative therapeutic strategies to treat antibiotic-resistant pathogens
Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …
ineffective, thus posing a threat to human health. The discovery of novel classes of …