Microglia heterogeneity in the single-cell era

T Masuda, R Sankowski, O Staszewski, M Prinz - Cell reports, 2020 - cell.com
Microglia are resident immune cells in the central nervous system (CNS) that are capable of
carrying out prominent and various functions during development and adulthood under both …

Microglia emerge as central players in brain disease

MW Salter, B Stevens - Nature medicine, 2017 - nature.com
There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …

[HTML][HTML] GABA-receptive microglia selectively sculpt develo** inhibitory circuits

E Favuzzi, S Huang, GA Saldi, L Binan, LA Ibrahim… - Cell, 2021 - cell.com
Microglia, the resident immune cells of the brain, have emerged as crucial regulators of
synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse …

Microglia in depression: current perspectives

X Jia, Z Gao, H Hu - Science China Life Sciences, 2021 - Springer
Major depressive disorder (MDD) is a prevalent psychiatric disease that involves
malfunctions of different cell types in the brain. Accumulating studies started to reveal that …

Bidirectional microglia–neuron communication in health and disease

Z Szepesi, O Manouchehrian, S Bachiller… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

[HTML][HTML] Sha** neuronal fate: functional heterogeneity of direct microglia-neuron interactions

C Cserép, B Pósfai, Á Dénes - Neuron, 2021 - cell.com
The functional contribution of microglia to normal brain development, healthy brain function,
and neurological disorders is increasingly recognized. However, until recently, the nature of …

Glia of the human retina

A Reichenbach, A Bringmann - Glia, 2020 - Wiley Online Library
The human retina contains three types of glial cells: microglia and two types of macroglia,
astrocytes and Müller cells. Macroglia provide homeostatic and metabolic support to …

Integrating neuroimmune systems in the neurobiology of depression

ES Wohleb, T Franklin, M Iwata… - Nature Reviews …, 2016 - nature.com
Data from clinical and preclinical studies indicate that immune dysregulation, specifically of
inflammatory processes, is associated with symptoms of major depressive disorder (MDD) …

Microglia: dynamic mediators of synapse development and plasticity

Y Wu, L Dissing-Olesen, BA MacVicar, B Stevens - Trends in immunology, 2015 - cell.com
Neuronal communication underlies all brain activity and the genesis of complex behavior.
Emerging research has revealed an unexpected role for immune molecules in the …

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

TL Tay, JC Savage, CW Hui, K Bisht… - The Journal of …, 2017 - Wiley Online Library
Microglia are the only immune cells that permanently reside in the central nervous system
(CNS) alongside neurons and other types of glial cells. The past decade has witnessed a …